Yajuan J. Liu, PhD, director of Clinical Genomics Laboratory, has published papers recently using Fusionplex RNA-seq in various cancers. The works were done in collaboration with colleagues in the University of Washington and other institutions.
- Mantilla JG, Ricciotti RW, Chen E, Hoch BL, Liu YJ. Detecting disease-defining gene fusions in unclassified round cell sarcomas using anchored multiplex PCR/targeted RNA next-generation sequencing-Molecular and clinicopathological characterization of 16 cases. Genes Chromosomes Cancer. 2019 Oct;58(10):713-722. PubMed PMID: 31033080.
- Tretiakova MS, Wang W, Wu Y, Tykodi SS, True L, and Liu YJ. Detection and Discovery of Translocations in Renal Cell Carcinoma by Fusionplex RNA Sequencing and Correlations of Molecular Findings with Clinicopathological Features. Genes Chromosomes Cancer. 2019 Aug 10. doi: 10.1002/gcc.22798. [Epub ahead of print] PubMed PMID: 31400230.
- Pattwell SS, Konnick EQ, Liu YJ, Yoda RA, Sekhar LN, Cimino PJ. Neurotrophic Receptor Tyrosine Kinase 2 (NTRK2) Alterations in Low-Grade Gliomas: Report of a Novel Gene Fusion Partner in a Pilocytic Astrocytoma and Review of the Literature. Case Rep Pathol. 2020 Jan 30;2020:5903863. doi: 10.1155/2020/5903863. eCollection 2020. PubMed PMID: 32082673; PubMed Central PMCID: PMC7013287.
- Davis JL, Vargas SO, Rudzinski ER, López Marti JM, Janeway K, Forrest S, Winsnes K, Pinto N, Yang SE, VanSandt M, Boyd TK, Corless CL, Liu YJ, Surrey LF, Harris MH, Church A, Al-Ibraheemi A. Recurrent RET Gene Fusions in Pediatric Spindle Mesenchymal Neoplasms. Histopathology. 2020 Jun;76(7):1032-1041. doi: 10.1111/his.14082. Epub 2020 May 15. PMID: 31994201.
- Han L, Liu YJ, Ricciotti RW, Mantilla JG. A novel MBTD1-PHF1 gene fusion in endometrial stromal sarcoma: A case report and literature review. Genes Chromosomes Cancer. 2020 Jul;59(7):428-432. doi: 10.1002/gcc.22845. Epub 2020 Apr 15. PMID: 32237188.
- Kuroda N, Trpkov K, Gao Y, Tretiakova M, Liu YJ, Ulamec M, Takeuchi K, Agaimy A, Przybycin C, Magi-Galluzzi C, Fushimi S, Kojima F, Sibony M, Hang JF, Pan CC, Yilmaz A, Siadat F, Sugawara E, Just PA, Ptakova N, Hes O. ALK rearranged renal cell carcinoma (ALK-RCC): a multi-institutional study of twelve cases with identification of novel partner genes CLIP1, KIF5B and KIAA1217. Mod Pathol. 2020 May 28. doi: 10.1038/s41379-020-0578-0. Epub ahead of print. PMID: 32467651.
- Mantilla JG, Gross JM, Liu YJ, Hoch BL, Ricciotti RW. Characterization of novel USP6 gene rearrangements in a subset of so-called cellular fibroma of tendon sheath. Mod Pathol. 2020 Jul 13. doi: 10.1038/s41379-020-0621-1. Epub ahead of print. PMID: 32661296.
- Michal M, Rubin BP, Agaimy A, Kosemehmetoglu K, Rudzinski ER, Linos K, John I, Gatalica Z, Davis JL, Liu YJ, McKenney JK, Billings SD, Švajdler M, Koshyk O, Kinkor Z, Michalová K, Kalmykova AV, Yusufli Z, Ptáková N, Hájková V, Grossman P, Šteiner P, Michal M. EWSR1-PATZ1nged sarcoma: a report of nine cases of spindle and round cell neoplasms with predilection for thoracoabdominal soft tissues and frequent expression of neural and skeletal muscle markers. Mod Pathol. 2020 Oct 4. doi: 10.1038/s41379-020-00684-8. Epub ahead of print. PMID: 33012788.
- Mantilla JG, Cheung H, Ha AS, Hoch BL, Liu YJ, Ricciotti RW. Spindle cell neoplasm with EML4-ALK gene fusion presenting as an intraosseous vertebral mass. Genes Chromosomes Cancer. 2021 Apr;60(4):282-286. doi: 10.1002/gcc.22917. Epub 2020 Nov 19. PMID: 33170538.
- Liu YJ, Wang W, Yeh J, Wu Y, Mantilla JG, Fletcher CDM, Ricciotti RW, Chen EY. Calcified chondroid mesenchymal neoplasms with FN1-receptor tyrosine kinase gene fusions including FGFR2, FGFR1, MERTK, NTRK1, and TEK: a molecular and clinicopathologic analysis. Mod Pathol. 2021 Mar 16. doi: 10.1038/s41379-021-00786-x. Epub ahead of print. PMID: 33727696.
- Liu YJ, Wagner MJ, Kim EY, and Chen EY. TUBA1A-GLI1 fusion in a soft tissue myoepithelial neoplasm. Hum Pathol. 2021 March; In press. [Epub ahead of print]
- Penning AJ, Al-Ibraheemi A, Michal M, Larsen BT, Cho SJ, Lockwood CM, Paulson VA, Liu YJ, Plank L, Fritchie K, Beadling C, Neff TL, Corless CL, Rudzinski ER, Davis JL. Novel BRAF gene fusions and activating point mutations in spindle cell sarcomas with histologic overlap with infantile fibrosarcoma. Mod Pathol. 2021 Apr 13. Epub ahead of print. PMID: 33850302.
- Tan SY, Al-Ibraheemi A, Ahrens WA, Oesterheld JE, Fanburg-Smith JC, Liu YJ, Spunt SL, Rudzinski ER, Coffin C, Davis JL. ALK rearrangements in infantile fibrosarcoma-like spindle cell tumours of soft tissue and kidney. Histopathology. 2022 Mar;80(4):698-707. doi: 10.1111/his.14603. Epub 2022 Jan 2. PMID: 34843129.